Functional characterization of tachykinin NK1 receptors in the mouse uterus
نویسندگان
چکیده
منابع مشابه
Functional and molecular characterization of tachykinins and tachykinin receptors in the mouse uterus.
The aim of this study was to analyze the function and expression of tachykinins, tachykinin receptors, and neprilysin (NEP) in the mouse uterus. A previous study showed that the uterotonic effects of substance P (SP), neurokinin A (NKA), and neurokinin B (NKB) in estrogen-treated mice were mainly mediated by the tachykinin NK1 receptor. In the present work, further contractility studies were un...
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BACKGROUND In the mouse uterus, pregnancy is accompanied by changes in tachykinin and tachykinin receptor gene expression and in the uterotonic effects of endogenous tachykinins. In this study we have investigated whether changes in tachykinin expression and responses are a result of changes in ovarian steroid levels. METHODS We quantified the mRNAs of tachykinins and tachykinin receptors in ...
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In the gastrointestinal tract, tachykinin NK1 receptors are widely distributed in a number of neuronal and nonneuronal cells involved in the control of gut motor activity. In particular, in the rabbit isolated distal colon, which is a suitable model system to investigate the contribution of tachykinins as noncholinergic excitatory transmitters, the influence of NK1 receptors in the regulation o...
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In rodent behavioural screens, such as the forced swim or resident/intruder tests, the behaviour of mice that lack functional substance P-preferring, tachykinin-1 receptors ((NK1R) either through drug antagonism or gene ablation) mimics that of wildtype mice that have been treated with an antidepressant drug. All antidepressants modify the function of monoamine-releasing neurones in the brain. ...
متن کاملSubstance P induction of itch-associated response mediated by cutaneous NK1 tachykinin receptors in mice.
Our experiments were conducted to determine whether substance P (SP) would elicit an itch sensation mediated by mast cells in mice. An intradermal injection of SP (10-135 microgram site-1) into the rostral back of the ICR mouse dose-dependently produced scratching of the injected site. The SP- (135 microgram site-1 = 100 nmol site-1) induced scratching was inhibited by capsaicin (repeated admin...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2002
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0704996